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Pharmacology: Mechanism of Action: Dicyclomine Hydrochloride is a tertiary amine with antimuscarinic effects similar to but weaker than those atropine; it also has a direct anti-spasmodic action. Simethicone lowers surface tension and when administered by mouth causes bubbles of gas in the gastro-intestinal tract to coalesce, thus aiding their dispersion.
Pharmacokinetics: Dicyclomine is used in gastrointestinal spasm, particularly that associated with the irritable bowel syndrome, and is also given in association with antacids as an adjunct in the treatment of peptic ulcer. Simethicone is used to relieve flatulence and abdominal discomfort due to excess gastrointestinal gas and also used as defoaming agent in radiography or endoscopy of the gastrointestinal tract.
